Univ.-Prof. Dr. med. Björn Scheffler

Direktor
DKFZ-Abteilung für Translationale Neuroonkologie am WTZ
DKTK Partnerstandort Universitätsklinikum Essen

Akademischer Werdegang

2016    W3 Professor für Translationale Onkologie mit Schwerpunkt Neuroonkologie/DKTK Professur
Universitätsklinikum Essen & Deutsches Krebsforschungszentrum Heidelberg

2008    W2 Professor Stamzellpathologien /Lichtenberg Professur
Institut für Rekonstruktive Neurobiologie am Universitätsklinikum Bonn

2005    Research Assistant Professor
Department of Neuroscience University of Florida, Gainesville, USA

2002    Visiting Assistant
McKnight Brain Institute, University of Florida, Gainesville, USA

1999    Assistenzarzt
Institut für Neuropathologie, Universitätsklinikum Bonn

1992    Medizinstudium
Universität Bonn & University of Tennessee, Memphis, USA

Expertisen

Neuropathologie, Entwicklungsneurobiologie, Stammzellen, Hirntumore, biotechnologische Forschung & Entwicklung, Technologietransfer und Medikamentenentwicklung, Konzeption früher klinischer Studien

Schlüsselpublikationen

Scheffler B, Horn M, Blümcke I, Laywell ED, Coomes D, Kukekov VG, Steindler DA (1999, cover article) Marrow-mindedness: A perspective on neuropoiesis. Trends Neurosci 22(8): 348-357.

Benninger F, Beck H, Wernig M, Tucker, KL, Brüstle O, Scheffler B (2003) Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures. J Neurosci 23(18): 7075-83.

Scheffler B, Walton NW, Lin DD, Goetz AK, Enikolopov G, Roper SN, Steindler DA (2005) Phenotypic and functional characterization of adult brain neuropoiesis. Proc Natl Acad Sci 102(26): 9253-8.

Goetz AK, Scheffler B*, Chen HX, Wang S, Xiang H, Suslov O, Brüstle O, Roper SN, Steindler DA (2006) Temporally restricted substrate interactions direct fate choice and specification of neural precursors derived from embryonic stem cells. Proc Natl Acad Sci USA 103(29): 11063-68. *shared first authorship

Walton NM, Sutter B, Chen HX, Chang LJ, Roper SN, Scheffler B*, Steindler DA (2006) Derivation and large-scale expansion of multipotent astroglial neural progenitors from adult human brain. Development 133(18): 3671-3681. *shared senior authorship

Wieland A, Trageser D, Gogolok S, Reinartz R, Höfer H, Keller M, Leinhaas A, Schelle R, Normann S, Klaas L, Waha A, Koch P, Fimmers R, Pietsch T, Yachnis T, Pincus D, Steindler DA, Brüstle O, Simon M, Glas M, Scheffler B (2013, cover article) Anticancer effects of niclosamide in human glioblastoma. Clin Cancer Res 19(15):4124-36.

Scheffler B, Simon M, Brüstle O, Herrlinger U, Glas M: Peripheral zone tumor cells, methods for their preparation and use: EP2324111 (2013); AU 2009291203 (2015); USPTO 9,103,819 (2015)

Reinartz R, Wang S, Kebir S, Silver DJ, Wieland A, Zheng T, Küpper M, Rauschenbach L, Fimmers R, Shepherd TM, Trageser D, Till A, Schäfer N, Glas M, Hillmer A, Cichon S, Smith AA, Pietsch T, Liu Y, Reynolds BA, Yachnis A, Pincus DW, Simon M, Brüstle O, Steindler DA, Scheffler B (2017, cover article) Functional subclone profiling for prediction of treatment-induced intratumor population shifts and discovery of rational drug combinations in human glioblastoma. Clin Cancer Res 23(2):562-74.

Kebir S, Hattingen E, Niessen M, Rauschbach L, Fimmers R, Hummel T, Schäfer N, Lazaridis L, Kleinschnitz C, Herrlinger U, Scheffler B*, Glas M (2019) Olfactory function as independent prognostic factor in glioblastoma. Neurology (accepted for publication). *shared senior authorship